Biomol/COX-2（人重组）/5 kU/Cay60122-5
商品编号：
Cay60122-5
品牌：
Biomol
市场价：
¥16880.00
美元价：
8440.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product information "COX-2 (human recombinant)"
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid (Cay-90010) to PGH2 (Cay-17020). Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 µM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme.
| Keywords: | COX2, PTGS2, COX-2, PHS II, PGHS-2, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2 synthase 2, Prostaglandin G/H synthase 2, Prostaglandin-endoperoxide synthase 2 |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 60122-5 |
Properties
| Application: | Enzyme activity |
| Conjugate: | No |
| Purity: | estimated by SDS-PAGE |
Database Information
| KEGG ID : | K11987 | Find alternatives |
| UniProt ID : | P35354 | Find alternatives |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -20°C (International: -80°C) |
Caution Our products are for laboratory research use only: Not for administration to humans!
品牌介绍
抗体在Biomol，您将找到适合您的研究的正确的多克隆或单克隆抗体。选择偶联（标记）的一抗（例如，FITC和生物素）用于抗原的直接免疫检测，或一抗加上二抗用于间接抗原检测。免疫球蛋白G类（IgG）的抗体主要用于免疫学检测。它们由四个蛋白质链组成：两条分子量为25 kDa的轻链（L）和两条分子量分别为50 kDa的重链（H）。由二硫键连接的重链和轻链（H + L）一起形成了众所周知的抗体结构。对于某些实验，这些免疫球蛋白的酶消化产生具有优势性质的抗体片段。
联络我们
